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Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses
Author(s) -
Schandock Franziska,
Riber Camilla Frich,
Röcker Annika,
Müller Janis A.,
Harms Mirja,
Gajda Paulina,
Zuwala Kaja,
Andersen Anna H. F.,
Løvschall Kaja Borup,
Tolstrup Martin,
Kreppel Florian,
Münch Jan,
Zelikin Alexander N.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700748
Subject(s) - ebola virus , zika virus , virology , broad spectrum , microbicides for sexually transmitted diseases , biology , medicine , virus , chemistry , population , environmental health , health services , combinatorial chemistry
Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad‐spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure–activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad‐spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer‐based antivirals and represent promising candidates for further development as preventive microbicides.