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Biomimetic Materials and Fabrication Approaches for Bone Tissue Engineering
Author(s) -
Kim Hwan D.,
Amirthalingam Sivashanmugam,
Kim Seunghyun L.,
Lee Seunghun S.,
Rangasamy Jayakumar,
Hwang Nathaniel S.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700612
Subject(s) - scaffold , tissue engineering , materials science , biomimetics , stem cell , bone tissue , nanotechnology , biomimetic materials , biomedical engineering , regeneration (biology) , microbiology and biotechnology , engineering , biology
Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypically stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo‐friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a microarchitecture design similar to native bone tissue are necessary for successful bone tissue regeneration. For this reason, various methods for fabricating 3D porous structures have been developed. Innovative techniques, such as 3D printing methods, are currently being utilized for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation. In this progress report, biomimetic materials and fabrication approaches that are currently being utilized for biomimetic scaffold design are reviewed.