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Organ‐on‐a‐Chip Systems for Women's Health Applications
Author(s) -
Nawroth Janna,
Rogal Julia,
Weiss Martin,
Brucker Sara Y.,
Loskill Peter
Publication year - 2018
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700550
Subject(s) - organ on a chip , organ system , female reproductive tract , biobank , endocrine system , physiology , function (biology) , disease , biology , hormone , bioinformatics , neuroscience , medicine , computational biology , pathology , microfluidics , endocrinology , microbiology and biotechnology , uterus , materials science , nanotechnology
Biomedical research, for a long time, has paid little attention to the influence of sex in many areas of study, ranging from molecular and cellular biology to animal models and clinical studies on human subjects. Many studies solely rely on male cells/tissues/animals/humans, although there are profound differences in male and female physiology, which can significantly impact disease mechanisms, toxicity of compounds, and efficacy of pharmaceuticals. In vitro systems have been traditionally very limited in their capacity to recapitulate female‐specific physiology and anatomy such as dynamic sex‐hormone levels and the complex interdependencies of female reproductive tract organs. However, the advent of microphysiological organ‐on‐a‐chip systems, which attempt to recreate the 3D structure and function of human organs, now gives researchers the opportunity to integrate cells and tissues from a variety of individuals. Moreover, adding a dynamic flow environment allows mimicking endocrine signaling during the menstrual cycle and pregnancy, as well as providing a controlled microfluidic environment for pharmacokinetic modeling. This review gives an introduction into preclinical and clinical research on women's health and discusses where organ‐on‐a‐chip systems are already utilized or have the potential to deliver new insights and enable entirely new types of studies.