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Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels
Author(s) -
Yang Degang,
Zhao Zhitong,
Bai Fan,
Wang Shutao,
Tomsia Antoni P.,
Bai Hao
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700472
Subject(s) - biocompatibility , materials science , tissue engineering , regeneration (biology) , scaffold , bone tissue , biomedical engineering , cell migration , nanotechnology , cell , chemistry , engineering , microbiology and biotechnology , biochemistry , metallurgy , biology
Ideal bone scaffolds having good biocompatibility, good biodegradability, and beneficial mechanical properties are the basis for bone tissue engineering. Specifically, cell migration within 3D scaffolds is crucial for bone regeneration of critical size defects. In this research, hydroxyapatite scaffolds with three different types of architectures (tortuous, parallel, and graded channels) are fabricated using the freeze‐casting (ice‐templating) method. While most studies promote cell migration by chemical factors, it can be greatly enhanced by introducing only graded channels as compared with tortuous or parallel channels. The results provide insights and guidance in designing novel scaffolds to enhance cell migration behavior for bone tissue regeneration.