Premium
Understanding the Effect of Surface Chemistry of Mesoporous Silica Nanorods on Their Vaccine Adjuvant Potency
Author(s) -
Yang Yannan,
Jambhrunkar Manasi,
Abbaraju Prasanna Lakshmi,
Yu Meihua,
Zhang Min,
Yu Chengzhong
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700466
Subject(s) - adjuvant , immune system , nanorod , mesoporous silica , antigen , chemistry , in vivo , immunopotentiator , potency , immunity , in vitro , secretion , biophysics , mesoporous material , nanotechnology , materials science , immunology , biology , biochemistry , catalysis , microbiology and biotechnology
Mesoporous silica nanoparticles are reported as adjuvants in nanovaccines in generating robust antigen‐specific immunity. However, the effect of surface chemistry in initiating and modulating the immune response remains largely unexplored. In this study, mesoporous silica nanorods (MSNRs) are modified with NH 2 and C 18 groups to investigate the influence of surface functional groups (OH, NH 2 , and C 18 ) on their adjuvant efficacy. It is found that compared to OH and NH 2 groups, the hydrophobic C 18 modification significantly enhances antigen uptake by antigen presenting cells and endosomal–lysosomal escape in vitro, dendritic cells, and macrophages maturation ex vivo, and elicits secretion of interferon‐γ level and antibody response in immunized mice. Moreover, bare MSNR and MSNRNH 2 exhibit T‐helper 2 biased immune response, while MSNRC 18 shows a T‐helper 1 biased immune response. These findings suggest that the surface chemistry of nanostructured adjuvants has profound impact on the immune response, which provides useful guidance for the design of effective nanomaterial based vaccines.