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Transparent and Gas‐Permeable Liquid Marbles for Culturing and Drug Sensitivity Test of Tumor Spheroids
Author(s) -
Li Hualin,
Liu Peng,
Kaur Guneet,
Yao Xi,
Yang Mengsu
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201700185
Subject(s) - spheroid , permeability (electromagnetism) , materials science , tumor cells , population , biophysics , chemistry , in vitro , cancer research , biology , medicine , biochemistry , membrane , environmental health
Transparent nanoparticle‐based liquid marbles with high gas‐permeability are prepared to culture tumor spheroids in 3D without the need of supplementary growth factor. The culturing process of spheroids from a population of cancer cells or a single cell in the transparent liquid marbles can be optically recorded continuously. Compared to monolayer cells and spheroids generated in multiwell plate, tumor spheroids cultured in the liquid marbles show enhanced viability under the treatment of chemotherapeutic drugs and small interfering RNA.