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Cellular Uptake: Assessing the Intracellular Integrity of Phosphine‐Stabilized Ultrasmall Cytotoxic Gold Nanoparticles Enabled by Fluorescence Labeling (Adv. Healthcare Mater. 24/2016)
Author(s) -
Broda Janine,
Küster Andrea,
Westhues Stefan,
Fahrenkamp Dirk,
Vogg Andreas T. J.,
Steitz Julia,
Mottaghy Felix M.,
MüllerNewen Gerhard,
Simon Ulrich
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670128
Subject(s) - fluorophore , fluorescence , ligand (biochemistry) , cytotoxic t cell , cytotoxicity , colloidal gold , nanotechnology , nanoparticle , biophysics , materials science , intracellular , phosphine , chemistry , in vitro , biochemistry , biology , catalysis , physics , receptor , quantum mechanics
On page 3118, a new hybrid structure consisting of a cytotoxic 1.4 nm sized gold core surrounded by a fluorophore‐containing ligand shell is designed to monitor cellular uptake by Ulrich Simon and co‐workers. The evolution of fluorescence upon cellular uptake discloses that the loss of the ligand shell or of parts of is the essential to unfold high AuNP cytotoxicity.