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Designed Stem Cell Aggregates: Enhanced Biological Functions of Human Mesenchymal Stem‐Cell Aggregates Incorporating E‐Cadherin‐Modified PLGA Microparticles (Adv. Healthcare Mater. 15/2016)
Author(s) -
Zhang Yan,
Mao Hongli,
Gao Chao,
Li Suhua,
Shuai Qizhi,
Xu Jianbin,
Xu Ke,
Cao Lei,
Lang Ren,
Gu Zhongwei,
Akaike Toshihiro,
Yang Jun
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670082
Subject(s) - mesenchymal stem cell , plga , stem cell , microbiology and biotechnology , cell growth , materials science , cadherin , cell , chemistry , nanotechnology , biology , biochemistry , nanoparticle
E‐cadherin‐modified poly(lactic‐co‐glycolic acid) (hE‐cad‐PLGA) microparticles were fabricated and then mediated the 3D cell aggregates of human mesenchymal stem cells (MSCs) on page 1949 by Jun Yang and co‐workers. The hE‐cad‐Fc matrix and the PLGA microparticles synergistically regulate the proliferation and bioactive factors secretions of MSCs by activating EGFR, AKT and ERK1/2 signaling pathways. The hE‐cad‐PLGA microparticles offer a novel route to expand multipotent stem cell‐based clinical applications.