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Photothermal Gene Delivery: Stimuli‐Regulated Enzymatically Degradable Smart Graphene‐Oxide‐Polymer Nanocarrier Facilitating Photothermal Gene Delivery (Adv. Healthcare Mater. 15/2016)
Author(s) -
Kim Hyunwoo,
Kim Jinhwan,
Lee Minkyung,
Choi Hee Cheul,
Kim Won Jong
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670080
Subject(s) - graphene , nanocarriers , photothermal therapy , gene delivery , oxide , nanotechnology , materials science , polymer , photothermal effect , rational design , biophysics , gene , chemistry , drug delivery , genetic enhancement , biochemistry , biology , metallurgy , composite material
On page 1918, Won Jong Kim and co‐workers use disulfide bonding for the rational design of graphene oxide (GO) based nanocarriers. In the lower left side, photothermally triggered gene release is illustrated in cancer cell. Polymer‐detached GOis exocytosed, and subsequently gets into the macrophage (middle right). In the macrophage, peroxidase binds to GO, thus degrades it to small fragments which are fluorescent.