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Targeted Cancer Therapy: pH‐Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin (Adv. Healthcare Mater. 15/2016)
Author(s) -
HerranzBlanco Bárbara,
Shahbazi MohammadAli,
Correia Alexandra R.,
Balasubramanian Vimalkumar,
Kohout Tomáš,
Hirvonen Jouni,
Santos Hélder A.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670076
Subject(s) - conjugate , doxorubicin , nanoparticle , drug delivery , cancer , intracellular , materials science , targeted drug delivery , cancer therapy , nanotechnology , magnetic nanoparticles , cancer research , chemistry , medicine , chemotherapy , biochemistry , mathematical analysis , mathematics
Targeted theranostic nanoparticles with dual pH and magnetic responsive properties for intracellular delivery are described by B. Herranz‐Blanco, H. A. Santos, and co‐workers on page 1904. Using a pH‐switch nanoprecipitation method in organic‐free solvents, a polymeric‐drug conjugate solid nanoparticle containing encapsulated superparamagnetic iron oxide nanoparticles and decorated with a tumor homing peptide, iRGD, are targeted to endothelial and metastatic cancer cells.