Targeted Cancer Therapy: pH‐Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin (Adv. Healthcare Mater. 15/2016) | Zendy

HerranzBlanco Bárbara | Zendy; Shahbazi MohammadAli | Zendy; Correia Alexandra R. | Zendy; Balasubramanian Vimalkumar | Zendy; Kohout Tomáš | Zendy; Hirvonen Jouni | Zendy; Santos Hélder A. | Zendy

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Targeted Cancer Therapy: pH‐Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin (Adv. Healthcare Mater. 15/2016)

Author(s) -

HerranzBlanco Bárbara,

Shahbazi MohammadAli,

Correia Alexandra R.,

Balasubramanian Vimalkumar,

Kohout Tomáš,

Hirvonen Jouni,

Santos Hélder A.

Publication year - 2016

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201670076

Subject(s) - conjugate , doxorubicin , nanoparticle , drug delivery , cancer , intracellular , materials science , targeted drug delivery , cancer therapy , nanotechnology , magnetic nanoparticles , cancer research , chemistry , medicine , chemotherapy , biochemistry , mathematical analysis , mathematics

Targeted theranostic nanoparticles with dual pH and magnetic responsive properties for intracellular delivery are described by B. Herranz‐Blanco, H. A. Santos, and co‐workers on page 1904. Using a pH‐switch nanoprecipitation method in organic‐free solvents, a polymeric‐drug conjugate solid nanoparticle containing encapsulated superparamagnetic iron oxide nanoparticles and decorated with a tumor homing peptide, iRGD, are targeted to endothelial and metastatic cancer cells.

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