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Cell‐Aligning Substrates: Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation (Adv. Healthcare Mater. 15/2016)
Author(s) -
Alapan Yunus,
Younesi Mousa,
Akkus Ozan,
Gurkan Umut A.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670075
Subject(s) - elongation , materials science , stiffness , pillar , substrate (aquarium) , mesenchymal stem cell , anisotropy , nanotechnology , optoelectronics , biophysics , composite material , optics , microbiology and biotechnology , structural engineering , physics , ultimate tensile strength , oceanography , biology , engineering , geology
On Page 1884, Y. Alapan, M. Younesi, O. Akkus, and U. A. Gurkan demonstrate a microfabricated pillar substrate to confine, align, and elongate cells for decoupled analysis of stiffness and directionality in 3D. Mesenchymal stem cells and cardiomyocytes are successfully confined in a 3D micromechanical environment with precisely tunable stiffness anisotropy. Cell alignment in the stiffer direction and extraordinary elongation is discovered with 3D cellular confinement in anisotropically stiff micropillar substrates.