Cell‐Aligning Substrates: Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation (Adv. Healthcare Mater. 15/2016) | Zendy

Alapan Yunus | Zendy; Younesi Mousa | Zendy; Akkus Ozan | Zendy; Gurkan Umut A. | Zendy

Premium

Cell‐Aligning Substrates: Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation (Adv. Healthcare Mater. 15/2016)

Author(s) -

Alapan Yunus,

Younesi Mousa,

Akkus Ozan,

Gurkan Umut A.

Publication year - 2016

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201670075

Subject(s) - elongation , materials science , stiffness , pillar , substrate (aquarium) , mesenchymal stem cell , anisotropy , nanotechnology , optoelectronics , biophysics , composite material , optics , microbiology and biotechnology , structural engineering , physics , ultimate tensile strength , oceanography , biology , engineering , geology

On Page 1884, Y. Alapan, M. Younesi, O. Akkus, and U. A. Gurkan demonstrate a microfabricated pillar substrate to confine, align, and elongate cells for decoupled analysis of stiffness and directionality in 3D. Mesenchymal stem cells and cardiomyocytes are successfully confined in a 3D micromechanical environment with precisely tunable stiffness anisotropy. Cell alignment in the stiffer direction and extraordinary elongation is discovered with 3D cellular confinement in anisotropically stiff micropillar substrates.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research