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Osteochondral Regeneration: Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral Regeneration (Adv. Healthcare Mater. 14/2016)
Author(s) -
Di Luca Andrea,
LorenzoMoldero Ivan,
Mota Carlos,
Lepedda Antonio,
Auhl Dietmar,
Van Blitterswijk Clemens,
Moroni Lorenzo
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670074
Subject(s) - scaffold , regeneration (biology) , mesenchymal stem cell , chondrogenesis , materials science , biomedical engineering , alkaline phosphatase , microbiology and biotechnology , chemistry , biology , medicine , biochemistry , enzyme
A combination of human mesenchymal stem cells with additive manufacturing technology for the fabrication of scaffolds with instructive properties is presented by Lorenzo Moroni and co‐workers on page 1753. This new fiber deposition pattern allows the generation of pores of different shapes within the same construct. The most rhomboidal pore geometry sustained enhances alkaline phosphatase activity and osteogenic related genes expression with respect to the other gradient zones when the gradient scaffold is cultured in a medium supporting both osteogenic and chondrogenic differentiation. This may contribute to enhance osteochondral regeneration in orthopedic treatments.