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Tissue Engineering: Mechanocompatible Polymer‐Extracellular‐Matrix Composites for Vascular Tissue Engineering (Adv. Healthcare Mater. 13/2016)
Author(s) -
Jiang Bin,
Suen Rachel,
Wang JiaoJing,
Zhang Zheng J.,
Wertheim Jason A.,
Ameer Guillermo A.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670067
Subject(s) - extracellular matrix , tissue engineering , intimal hyperplasia , materials science , biomedical engineering , matrix (chemical analysis) , vascular smooth muscle , polymer , vascular tissue , composite number , composite material , smooth muscle , microbiology and biotechnology , medicine , biology , botany
Heparinized mechanocompatible polymer‐extracellular matrix (ECM) composites to improve vascular graft performance are presented by J. A. Wertheim, G. A. Ameer, and co‐workers on page 1594. Polymer‐coated ECM is visualized by the purple color. The composite vascular graft reduced intimal hyperplasia in a rodent model, revealed by α‐smooth muscle actin staining (green). The method shows promise for tissue engineering where immobilization of bioactive molecules is desirable.