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Electrospun Scaffolds: Enhanced Lineage‐Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds (Adv. Healthcare Mater. 12/2016)
Author(s) -
Maldonado Maricela,
Ico Gerardo,
Low Karen,
Luu Rebeccah J.,
Nam Jin
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670062
Subject(s) - induced pluripotent stem cell , stem cell , human induced pluripotent stem cells , tissue engineering , materials science , scaffold , microbiology and biotechnology , cellular differentiation , nanotechnology , biomedical engineering , chemistry , biology , embryonic stem cell , medicine , gene , biochemistry
Electrospun scaffolds provide soft nanofibrous networks pliable by human induced pluripotent stem cells. J. Nam and co‐workers show on page 1408 that such compliant scaffolding leads to the formation of stem cell colonies with a distinctive three‐dimensional morphology. The morphological modulation resulted in the lineage‐specific differentiation, suggesting a potential means to enhance translational applications of the stem cells.