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Targeted Drug Delivery: Carbon‐Quantum‐Dots‐Loaded Mesoporous Silica Nanocarriers with pH‐Switchable Zwitterionic Surface and Enzyme‐Responsive Pore‐Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Healthcare Mater. 12/2016)
Author(s) -
Liu Zhongning,
Chen Xin,
Zhang Xiaojin,
Gooding John Justin,
Zhou Yongsheng
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670058
Subject(s) - nanocarriers , mesoporous silica , drug delivery , nanotechnology , targeted drug delivery , materials science , drug , biophysics , drug carrier , mesoporous material , chemistry , pharmacology , biochemistry , medicine , biology , catalysis
On page 1401 X. Chen, X. Zhang, Y. Zhou, and co‐workers describe the synthesis of mesoporous silica nanocarriers with pH‐switchable antifouling zwitterionic surfaces and blue fluorescence that are capable of enzyme‐responsive drug release. The system combines tumor treatment and tracking. It shows great potential for cancer treatment, since it exhibits prolonged circulation in the blood system with zero premature release while offering selective cellular uptake, tumor labeling, and intracellular drug release in tumor tissue.