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Targeted Cancer Therapy: Correlative Light‐Electron Microscopy Shows RGD‐Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016)
Author(s) -
Othman Basmah A.,
Greenwood Christina,
Abuelela Ayman F.,
Bharath Anil A.,
Chen Shu,
Theodorou Ioannis,
Douglas Trevor,
Uchida Maskai,
Ryan Mary,
Merzaban Jasmeen S.,
Porter Alexandra E.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670053
Subject(s) - triple negative breast cancer , targeted therapy , cancer cell , breast cancer , cancer research , cytotoxic t cell , materials science , cancer , intracellular , nanotechnology , apoptosis , biophysics , medicine , chemistry , biology , biochemistry , in vitro
On page 1310 J. S. Merzaban, A. E. Porter, and co‐workers present fluorescently labeled RGD‐targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light‐electron microscopy shows that NPs dissolve into ionic Zn 2+ (blue) upon uptake and cause apoptosis (red) with intra‐tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. Cover design by Ivan Gromicho.
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