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Photothermal Therapy: Cancer Cell Internalization of Gold Nanostars Impacts Their Photothermal Efficiency In Vitro and In Vivo: Toward a Plasmonic Thermal Fingerprint in Tumoral Environment (Adv. Healthcare Mater. 9/2016)
Author(s) -
Espinosa Ana,
Silva Amanda K. A.,
SánchezIglesias Ana,
Grzelczak Marek,
Péchoux Christine,
Desboeufs Karine,
LizMarzán Luis M.,
Wilhelm Claire
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670046
Subject(s) - photothermal therapy , internalization , in vivo , materials science , plasmon , nanotechnology , cancer , in vitro , cancer research , medicine , cell , optoelectronics , chemistry , biology , biochemistry , microbiology and biotechnology
Because the ultimate target for photothermal therapy is the cancer cell, heating performances must be evaluated intracellularly. On page 1040 C. Wilhelm and team provide the first in vitro and in vivo photothermal measurements in cancer cells with gold nanostars. They demonstrate that once nanostars are internalized within endosomes, heat generation can change significantly.