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Antibacterial Mechanisms: Toward a Molecular Understanding of the Antibacterial Mechanism of Copper‐Bearing Titanium Alloys against Staphylococcus aureus (Adv. Healthcare Mater. 5/2016)
Author(s) -
Li Mei,
Ma Zheng,
Zhu Ye,
Xia Hong,
Yao Mengyu,
Chu Xiao,
Wang Xiaolan,
Yang Ke,
Yang Mingying,
Zhang Yu,
Mao Chuanbin
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201670021
Subject(s) - staphylococcus aureus , bacteria , titanium , copper , bearing (navigation) , membrane , microbiology and biotechnology , antibacterial activity , materials science , reactive oxygen species , chemistry , metallurgy , biology , biochemistry , genetics , cartography , geography
On page 557, M. Yang, Y. Zhang, and C. Mao show how Cu ions released from the Cu‐bearing biomedical titanium alloys break the membranes of the bacteria, induce the production of excessive reactive oxygen species (ROS) and interfere with gene expression. Together, these effects cause the killing of Gram‐positive bacteria Staphylococcus aureus and lead to the excellent antibacterial properties of the Cu‐bearing biomedical titanium alloys.