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Stable Titania Nanostructures on Stainless Steel Coronary Stent Surface for Enhanced Corrosion Resistance and Endothelialization
Author(s) -
Mohan Chandini C.,
Cherian Aleena Mary,
Kurup Sujish,
Joseph John,
Nair Manitha B.,
Vijayakumar Maniyal,
Nair Shantikumar V.,
Me Deepthy
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601353
Subject(s) - restenosis , materials science , stent , in vivo , biomedical engineering , nanotechnology , medicine , microbiology and biotechnology , biology
Stainless steel (SS) coronary stents continue to present risk of in‐stent restenosis that impact its long term safety and efficacy. The present work focuses on developing a drug‐free and polymer‐less surface on coronary stents by utilizing a titania (TiO 2 ) nanotexturing approach through hydrothermal processing, that will offer improved stent performance in vivo. Mechanically stable and durable nanotextured coatings are obtained on SS stents that also offer good corrosion resistance. In vitro vascular cell (endothelial and smooth muscle cells) studies on surface modified SS show preferential rapid endothelialization with enhanced nitric oxide production and reduce smooth muscle cell proliferation, in comparison to unmodified SS. In vivo evaluation of the nanotextured stents after subcutaneous implantation in rabbits show reduced irritability and minimal localized inflammatory response. These beneficial effects suggest that the stable, easily scalable titania nanosurface modification strategy on coronary stent surfaces can be a much cheaper alternative to drug eluting stents in addressing in‐stent restenosis.