Premium
Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy
Author(s) -
Wong Hoi Man,
Zhao Ying,
Leung Frankie K. L.,
Xi Tingfei,
Zhang Zhixiong,
Zheng Yufeng,
Wu Shuilin,
Luk Keith D. K.,
Cheung Kenneth M. C.,
Chu Paul K.,
Yeung Kelvin W. K.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601269
Subject(s) - materials science , crystallinity , coating , magnesium , polycaprolactone , magnesium alloy , chemical engineering , polymer , simulated body fluid , composite material , nanoindentation , biomedical engineering , metallurgy , scanning electron microscope , medicine , engineering
To achieve enhanced biological response and controlled degradation of magnesium alloy, a modified biodegradable polymer coating called polycaprolactone (PCL) is fabricated by a thermal approach in which the heat treatment neither alters the chemical composition of the PCL membrane nor the rate of magnesium ion release, pH value, or weight loss, compared with the untreated sample. The changes in the crystallinity, hydrophilicity, and oxygen content of heat‐treated PCL coating not only improve the mechanical adhesion strength between the coating and magnesium substrate but also enhance the biological properties. Moreover, the thermally modified sample can lead to higher spreading and elongation of osteoblasts, due to the enhanced hydrophilicity and CO to CO functional group ratio. In the analyses of microcomputed tomography from one to four weeks postoperation, the total volume of new bone formation on the heat‐treated sample is 10%–35% and 70%–90% higher than that of the untreated and uncoated controls, respectively. Surprisingly, the indentation modulus of the newly formed bone adjacent to the heat‐treated sample is ≈20% higher than that of both controls. These promising results reveal the clinical potential of the modified PCL coating on magnesium alloy in orthopedic applications.