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Biofunctionalized Plants as Diverse Biomaterials for Human Cell Culture
Author(s) -
Fontana Gianluca,
Gershlak Joshua,
Adamski Michal,
Lee JaeSung,
Matsumoto Shion,
Le Hau D.,
Binder Bernard,
Wirth John,
Gaudette Glenn,
Murphy William L.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601225
Subject(s) - decellularization , tissue engineering , biomaterial , nanotechnology , materials science , cell adhesion , adhesion , biomedical engineering , biochemical engineering , engineering , composite material
The commercial success of tissue engineering products requires efficacy, cost effectiveness, and the possibility of scaleup. Advances in tissue engineering require increased sophistication in the design of biomaterials, often challenging the current manufacturing techniques. Interestingly, several of the properties that are desirable for biomaterial design are embodied in the structure and function of plants. This study demonstrates that decellularized plant tissues can be used as adaptable scaffolds for culture of human cells. With simple biofunctionalization technique, it is possible to enable adhesion of human cells on a diverse set of plant tissues. The elevated hydrophilicity and excellent water transport abilities of plant tissues allow cell expansion over prolonged periods of culture. Moreover, cells are able to conform to the microstructure of the plant frameworks, resulting in cell alignment and pattern registration. In conclusion, the current study shows that it is feasible to use plant tissues as an alternative feedstock of scaffolds for mammalian cells.