Premium
Hematite‐Based Photoelectrode Materials for Photoelectrocatalytic Inhibition of Alzheimer's β‐Amyloid Self‐Assembly
Author(s) -
Kim Kayoung,
Lee Byung Il,
Chung You Jung,
Choi Woo Seok,
Park Chan Beum
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601133
Subject(s) - hematite , oxidizing agent , radical , photochemistry , materials science , chemical engineering , chemistry , organic chemistry , engineering , metallurgy
A visible light‐active, hematite‐based photoelectrode platform for suppressing β‐amyloid (Aβ) self‐assembly in vitro is reported. Upon illumination of a light‐emitting diode with an anodic bias, the hematite photoanode generates reactive radical species, such as superoxide ions and hydroxyl radicals, via photoelectrocatalytic process. According to our analyses, the hematite photoanode exhibited a strong inhibitory effect on Aβ aggregation under visible light illumination and anodic bias. We found that hole‐derived radicals played a significant role of oxidizing Aβ peptides, which effectively blocked further aggregation. The efficacy of photoelectrocatalytic inhibition on Aβ aggregation was enhanced by introducing cobalt phosphate (Co‐Pi) as a co‐catalyst on the hematite photoanode, which facilitated the separation of electron‐hole pairs. We verified that both bare and Co‐Pi@hematite photoanodes are biocompatible and effective in reducing Aβ aggregation‐induced cytotoxicity.