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Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response
Author(s) -
Patel Dharmesh,
Sharma Sadhana,
Bryant Stephanie J.,
Screen Hazel R. C.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601095
Subject(s) - mechanotransduction , tendon , materials science , composite number , elastin , fiber , composite material , shear (geology) , biomedical engineering , stiffness , tension (geology) , anatomy , compression (physics) , microbiology and biotechnology , engineering , medicine , pathology , biology
A fiber composite system is presented which recapitulates the fiber‐composite‐like nature of tissues and generates similar modes of shear and tension. The shear/tension ratio can be customized during composite manufacture and incorporates viable cells. The system is a valuable tool for mechanotransduction research, providing a platform with physiologically relevant conditions for investigating cell behavior in different tissue types.