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A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings
Author(s) -
Yesilyurt Volkan,
Veiseh Omid,
Doloff Joshua C.,
Li Jie,
Bose Suman,
Xie Xi,
Bader Andrew R.,
Chen Michael,
Webber Matthew J.,
Vegas Arturo J.,
Langer Robert,
Anderson Daniel G.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601091
Subject(s) - biomaterial , materials science , nanotechnology , surface modification , chemical engineering , engineering
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel‐mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.