Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent | Zendy

Xin Qi | Zendy; Liu Qian | Zendy; Geng Lingling | Zendy; Fang Qiaojun | Zendy; Gong Jian Ru | Zendy

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Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent

Author(s) -

Xin Qi,

Liu Qian,

Geng Lingling,

Fang Qiaojun,

Gong Jian Ru

Publication year - 2017

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201601011

Subject(s) - dna ligase , nanoparticle , peptidoglycan , nanotechnology , combinatorial chemistry , antimicrobial , chemistry , computer science , computational biology , materials science , enzyme , biochemistry , biology , organic chemistry

d ‐type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L‐type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.

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