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Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent
Author(s) -
Xin Qi,
Liu Qian,
Geng Lingling,
Fang Qiaojun,
Gong Jian Ru
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201601011
Subject(s) - dna ligase , nanoparticle , peptidoglycan , nanotechnology , combinatorial chemistry , antimicrobial , chemistry , computer science , computational biology , materials science , enzyme , biochemistry , biology , organic chemistry
d ‐type functionalized nanoparticles (NPs) can bind to MurD ligase with high affinity and inhibit its peptidoglycan synthetic enzyme activity, and finally cause bacterial killing. In contrast, its L‐type counterpart displays a negligible effect, indicating that the chiral structure of the functionalized NPs plays an essential role in their binding interaction with MurD and therefore the antibacterial activity.