Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments | Zendy

Kamperman Tom | Zendy; Henke Sieger | Zendy; van den Berg Albert | Zendy; Shin Su Ryon | Zendy; Tamayol Ali | Zendy; Khademhosseini Ali | Zendy; Karperien Marcel | Zendy; Leijten Jeroen | Zendy

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Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments

Author(s) -

Kamperman Tom,

Henke Sieger,

van den Berg Albert,

Shin Su Ryon,

Tamayol Ali,

Khademhosseini Ali,

Karperien Marcel,

Leijten Jeroen

Publication year - 2017

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201600913

Subject(s) - biofabrication , modular design , nanotechnology , materials science , cell mechanics , cell , tissue engineering , computer science , biomedical engineering , chemistry , engineering , biochemistry , cytoskeleton , operating system

Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro‐ and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modular design of native tissues with a single cell resolution. This approach represents a major step forward in endowing engineered constructs with the multifunctionality that underlies the behavior of native tissues.

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