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Local Delivery of PHD2 siRNA from ROS‐Degradable Scaffolds to Promote Diabetic Wound Healing
Author(s) -
Martin John R.,
Nelson Christopher E.,
Gupta Mukesh K.,
Yu Fang,
Sarett Samantha M.,
Hocking Kyle M.,
Pollins Alonda C.,
Nanney Lillian B.,
Davidson Jeffrey M.,
Guelcher Scott A.,
Duvall Craig L.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600820
Subject(s) - small interfering rna , wound healing , microbiology and biotechnology , reactive oxygen species , tissue engineering , chemistry , cancer research , rna , biomedical engineering , medicine , biochemistry , gene , biology , immunology
Small interfering RNA (siRNA) delivered from reactive oxygen species‐degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal‐urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.