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Copolymer‐Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo
Author(s) -
Crowder Spencer W.,
Balikov Daniel A.,
Boire Timothy C.,
McCormack Devin,
Lee Jung Bok,
Gupta Mukesh K.,
Skala Melissa C.,
Sung HakJoon
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600819
Subject(s) - mesenchymal stem cell , in vivo , in vitro , microbiology and biotechnology , cell , stem cell , biomaterial , materials science , chemistry , biophysics , nanotechnology , biology , biochemistry
Material‐induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell‐repellent and cell‐adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.