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Hydrogel Functionalized Janus Membrane for Skin Regeneration
Author(s) -
An YoungHyeon,
Yu Seung Jung,
Kim In Seon,
Kim SuHwan,
Moon JeongMi,
Kim Seunghyun L.,
Choi Young Hwan,
Choi Joon Sig,
Im Sung Gap,
Lee Kyung Eun,
Hwang Nathaniel S.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600795
Subject(s) - janus , membrane , permeation , methacrylate , materials science , chemical engineering , polymer chemistry , surface modification , self healing hydrogels , contact angle , chemistry , polymer , composite material , copolymer , nanotechnology , biochemistry , engineering
In this study, a hydrogel functionalized Janus membrane is developed and its capacity is examined as a wound dressing biomaterial. A hydrophobic fluoropolymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10‐heptadecafluorodecyl methacrylate) (PHFDMA), is uniformly coated onto macroporous polyester membrane through initiated chemical vapor deposition process on both sides. PHFDMA‐coated macroporous membrane exhibits antibacterial property, allows air permeation, and inhibits water penetration. Janus membrane property is obtained by exposing one side of PHFDMA coated membrane with 1 m KOH solution, which allows PHFDMA cleavage resulting in carboxylic acid residue. This carboxylic acid residue is then further functionalized with gelatin methacrylate‐based photocrosslinkable hydrogel for moisture retention and growth factor release. When applied to full thickness dorsal skin defect model, functionalized hydrogel allows moisture retention and hydrophobic surface prevents exudate leaks via water repellence. Furthermore, hydrogel functionalized Janus membrane enhances the wound healing rate and induces thick epidermal layer formation. In conclusion, the multifunctional Janus membrane with hydrophobic outer surface and immobilized hydrogel on the other surface is fabricated for an innovative strategy for wound healing.