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Ebola Vaccination Using a DNA Vaccine Coated on PLGA‐PLL/γPGA Nanoparticles Administered Using a Microneedle Patch
Author(s) -
Yang HungWei,
Ye Ling,
Guo Xin Dong,
Yang Chinglai,
Compans Richard W.,
Prausnitz Mark R.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600750
Subject(s) - immunogenicity , dna vaccination , plga , vaccination , nasal administration , nanoparticle , medicine , materials science , adjuvant , virology , immune system , pharmacology , immunization , nanotechnology , immunology
Ebola DNA vaccine is incorporated into PLGA‐PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.