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Hyaluronic Acid/PLGA Core/Shell Fiber Matrices Loaded with EGCG Beneficial to Diabetic Wound Healing
Author(s) -
Shin Yong Cheol,
Shin DongMyeong,
Lee Eun Ji,
Lee Jong Ho,
Kim Ji Eun,
Song Sung Hwa,
Hwang DaeYoun,
Lee Jun Jae,
Kim Bongju,
Lim Dohyung,
Hyon SuongHyu,
Lim YoungJun,
Han DongWook
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600658
Subject(s) - plga , hyaluronic acid , wound healing , glycolic acid , materials science , electrospinning , biomedical engineering , biophysics , surgery , composite material , lactic acid , nanotechnology , medicine , polymer , anatomy , genetics , biology , nanoparticle , bacteria
During the last few decades, considerable research on diabetic wound healing strategies has been performed, but complete diabetic wound healing remains an unsolved problem, which constitutes an enormous biomedical burden. Herein, hyaluronic acid (HA)/poly(lactic‐ co ‐glycolic acid, PLGA) core/shell fiber matrices loaded with epigallocatechin‐3 ‐O‐ gallate (EGCG) (HA/PLGA‐E) are fabricated by coaxial electrospinning. HA/PLGA‐E core/shell fiber matrices are composed of randomly‐oriented sub‐micrometer fibers and have a 3D porous network structure. EGCG is uniformly dispersed in the shell and sustainedly released from the matrices in a stepwise manner by controlled diffusion and PLGA degradation over four weeks. EGCG does not adversely affect the thermomechanical properties of HA/PLGA‐E matrices. The number of human dermal fibroblasts attached on HA/PLGA‐E matrices is appreciably higher than that on HA/PLGA counterparts, while their proliferation is steadily retained on HA/PLGA‐E matrices. The wound healing activity of HA/PLGA‐E matrices is evaluated in streptozotocin‐induced diabetic rats. After two weeks of surgical treatment, the wound areas are significantly reduced by the coverage with HA/PLGA‐E matrices resulting from enhanced re‐epithelialization/neovascularization and increased collagen deposition, compared with no treatment or HA/PLGA. In conclusion, the HA/PLGA‐E matrices can be potentially exploited to craft strategies for the acceleration of diabetic wound healing and skin regeneration.