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Modeling the Human Scarred Heart In Vitro: Toward New Tissue Engineered Models
Author(s) -
Deddens Janine C.,
Sadeghi Amir Hossein,
Hjortnaes Jesper,
van Laake Linda W.,
Buijsrogge Marc,
Doevendans Pieter A.,
Khademhosseini Ali,
Sluijter Joost P. G.
Publication year - 2017
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600571
Subject(s) - tissue engineering , heart failure , fibrosis , extracellular matrix , medicine , cardiac fibrosis , risk analysis (engineering) , neuroscience , intensive care medicine , biomedical engineering , cardiology , pathology , biology , microbiology and biotechnology
Cardiac remodeling is critical for effective tissue healing, however, excessive production and deposition of extracellular matrix components contribute to scarring and failing of the heart. Despite the fact that novel therapies have emerged, there are still no lifelong solutions for this problem. An urgent need exists to improve the understanding of adverse cardiac remodeling in order to develop new therapeutic interventions that will prevent, reverse, or regenerate the fibrotic changes in the failing heart. With recent advances in both disease biology and cardiac tissue engineering, the translation of fundamental laboratory research toward the treatment of chronic heart failure patients becomes a more realistic option. Here, the current understanding of cardiac fibrosis and the great potential of tissue engineering are presented. Approaches using hydrogel‐based tissue engineered heart constructs are discussed to contemplate key challenges for modeling tissue engineered cardiac fibrosis and to provide a future outlook for preclinical and clinical applications.