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Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation
Author(s) -
Cai Lei,
Dewi Ruby E.,
Goldstone Andrew B.,
Cohen Jeffrey E.,
Steele Amanda N.,
Woo Y. Joseph,
Heilshorn Sarah C.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600497
Subject(s) - self healing hydrogels , in situ , stem cell , materials science , cell encapsulation , microbiology and biotechnology , stem cell niche , stiffening , progenitor cell , biophysics , chemistry , biology , composite material , polymer chemistry , organic chemistry
A family of shear‐thinning hydrogels for injectable encapsulation and long‐term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200–400 Pa) could significantly promote the angiogenic potential of human adipose‐derived stem cells.