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Simultaneously Photo‐Cleavable and Activatable Prodrug‐Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery
Author(s) -
Zhou Dongfang,
Guo Jinshan,
Kim Gloria B.,
Li Jizhen,
Chen Xuesi,
Yang Jian,
Huang Yubin
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600470
Subject(s) - prodrug , micelle , copolymer , drug delivery , drug , anticancer drug , biocompatible material , chemistry , block (permutation group theory) , computer science , combinatorial chemistry , materials science , nanotechnology , pharmacology , medicine , organic chemistry , biochemistry , biomedical engineering , mathematics , aqueous solution , polymer , geometry
A simultaneously photo‐cleavable and activatable prodrug‐backboned block copolymer (BCP) micelle strategy is demonstrated. Without light treatment, the micelles stay silent and inactivated, being biocompatible to normal tissues. Concurrent chain cleavage of BCP micelles and the activation of Pt(IV) prodrug could be temporally and spatially triggered by UV or even visible light for precise anticancer drug delivery.