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Synthesis of Ferromagnetic Fe 0.6 Mn 0.4 O Nanoflowers as a New Class of Magnetic Theranostic Platform for In Vivo T 1 ‐T 2 Dual‐Mode Magnetic Resonance Imaging and Magnetic Hyperthermia Therapy
Author(s) -
Liu Xiao Li,
Ng Cheng Teng,
Chandrasekharan Prashant,
Yang Hai Tao,
Zhao Ling Yun,
Peng Erwin,
Lv Yun Bo,
Xiao Wen,
Fang Jie,
Yi Jia Bao,
Zhang Huan,
Chuang KaiHsiang,
Bay Boon Huat,
Ding Jun,
Fan Hai Ming
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600357
Subject(s) - in vivo , magnetic resonance imaging , hyperthermia , materials science , dual mode , nuclear magnetic resonance , magnetic hyperthermia , ferromagnetism , biomedical engineering , nanotechnology , magnetic nanoparticles , nanoparticle , condensed matter physics , medicine , radiology , physics , biology , aerospace engineering , microbiology and biotechnology , engineering
Uniform wüstite Fe 0.6 Mn 0.4 O nanoflowers have been successfully developed as an innovative theranostic agent with T 1 ‐T 2 dual‐mode magnetic resonance imaging (MRI), for diagnostic applications and therapeutic interventions via magnetic hyperthermia. Unlike their antiferromagnetic bulk counterpart, the obtained Fe 0.6 Mn 0.4 O nanoflowers show unique room‐temperature ferromagnetic behavior, probably due to the presence of an exchange coupling effect. Combined with the flower‐like morphology, ferromagnetic Fe 0.6 Mn 0.4 O nanoflowers are demonstrated to possess dual‐modal MRI sensitivity, with longitudinal relaxivity r 1 and transverse relaxivity r 2 as high as 4.9 and 61.2 m m −1 s −1 [Fe]+[Mn], respectively. Further in vivo MRI carried out on the mouse orthotopic glioma model revealed gliomas are clearly delineated in both T 1 ‐ and T 2 ‐weighted MR images, after administration of the Fe 0.6 Mn 0.4 O nanoflowers. In addition, the Fe 0.6 Mn 0.4 O nanoflowers also exhibit excellent magnetic induction heating effects. Both in vitro and in vivo magnetic hyperthermia experimentation has demonstrated that magnetic hyperthermia by using the innovative Fe 0.6 Mn 0.4 O nanoflowers can induce MCF‐7 breast cancer cell apoptosis and a complete tumor regression without appreciable side effects. The results have demonstrated that the innovative Fe 0.6 Mn 0.4 O nanoflowers can be a new magnetic theranostic platform for in vivo T 1 ‐T 2 dual‐mode MRI and magnetic thermotherapy, thereby achieving a one‐stop diagnosis cum effective therapeutic modality in cancer management.