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Photocatalytic Degradation of Cell Membrane Coatings for Controlled Drug Release
Author(s) -
Rao Lang,
Meng QianFang,
Huang Qinqin,
Liu Pei,
Bu LinLin,
Kondamareddy Kiran Kumar,
Guo ShiShang,
Liu Wei,
Zhao XingZhong
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600303
Subject(s) - nanocarriers , drug delivery , materials science , membrane , drug , nanoparticle , nanotechnology , degradation (telecommunications) , cell membrane , targeted drug delivery , drug carrier , biophysics , chemistry , pharmacology , biochemistry , medicine , telecommunications , computer science , biology
Biomimetic cell‐membrane–camouflaged particles with desirable features have been widely used for various biomedical applications. However, there are few reports on employing these particles for cancer drug delivery due to the failure of the membrane coatings to be efficiently degraded in the tumor microenvironment which hampers the drug release. In this work, core–shell SiO 2 @TiO 2 nanoparticles with enhanced photocatalytic activity are used for controlled degradation of surface erythrocyte membrane coatings. The antitumor drug docetaxel is encapsulated into nanocarriers to demonstrate the controlled drug release under ultraviolet irradiation, and the drug‐loaded nanoparticles are further used for enhanced cancer cell therapy. Here, a simple but practical method for degradation of cell membrane coatings is presented, and a good feasibility of using cell membrane–coated nanocarriers for controlled drug delivery is demonstrated.