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Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces
Author(s) -
Sapudom Jiranuwat,
Rubner Stefan,
Martin Steve,
Pompe Tilo
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600295
Subject(s) - extracellular matrix , computer science , extracellular , computational biology , topology (electrical circuits) , nanotechnology , biology , microbiology and biotechnology , materials science , mathematics , combinatorics
Engineering interfaces of distinct extracellular compartments mimicking native tissues are key for in‐depth in vitro studies on developmental and disease processes in biology and medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar collagen I networks with a multiparameter control of topology, mechanics, and composition, and their distinct impact on triggering the directionality of cancer cell migration is demonstrated.