A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens | Zendy

Gallagher Andrew G. | Zendy; Alorabi Jamal A. | Zendy; Wellings Donald A. | Zendy; Lace Rebecca | Zendy; Horsburgh Mal J. | Zendy; Williams Rachel L. | Zendy

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A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens

Author(s) -

Gallagher Andrew G.,

Alorabi Jamal A.,

Wellings Donald A.,

Lace Rebecca,

Horsburgh Mal J.,

Williams Rachel L.

Publication year - 2016

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201600258

Subject(s) - bandage , keratitis , cornea , antimicrobial , contact lens , medicine , corneal ulcer , penicillin , antibiotics , staphylococcus aureus , dermatology , ophthalmology , microbiology and biotechnology , surgery , biology , bacteria , genetics

A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly‐ε‐lysine and is positive against Staphylococcus aureus and Escherichia coli . The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug‐eluting bandage lens replacing conventional corneal ulcer treatment.

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