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A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens
Author(s) -
Gallagher Andrew G.,
Alorabi Jamal A.,
Wellings Donald A.,
Lace Rebecca,
Horsburgh Mal J.,
Williams Rachel L.
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600258
Subject(s) - bandage , keratitis , cornea , antimicrobial , contact lens , medicine , corneal ulcer , penicillin , antibiotics , staphylococcus aureus , dermatology , ophthalmology , microbiology and biotechnology , surgery , biology , bacteria , genetics
A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly‐ε‐lysine and is positive against Staphylococcus aureus and Escherichia coli . The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug‐eluting bandage lens replacing conventional corneal ulcer treatment.