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In Vivo MRI and X‐Ray Bifunctional Imaging of Polymeric Composite Supplemented with GdPO 4 ·H 2 O Nanobundles for Tracing Bone Implant and Bone Regeneration
Author(s) -
Huang Jing,
Lv Zhongwen,
Wang Yu,
Wang Zongliang,
Gao Tianlin,
Zhang Ning,
Guo Min,
Zou Haifeng,
Zhang Peibiao
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600249
Subject(s) - materials science , implant , homogeneous , plga , bifunctional , composite number , dispersity , nanotechnology , computer science , biomedical engineering , chemistry , composite material , physics , polymer chemistry , medicine , surgery , organic chemistry , nanoparticle , thermodynamics , catalysis
Homogeneous and monodisperse GdPO 4 ·H 2 O nanobundles are successfully synthesized via a solvothermal method. Then, GdPO 4 ·H 2 O are incorporated into the composite of hydroxyapatite and poly(lactic‐co‐glycolic acid) to obtain a biodegradable and traceable bone implant. After implanted, the GdPO 4 ·H 2 O/HA/PLGA implant and the newly formed bone can be easily traced and observed through the combination of magnetic resonance imaging and X‐ray imaging.