Enhanced Lineage‐Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds | Zendy

Maldonado Maricela | Zendy; Ico Gerardo | Zendy; Low Karen | Zendy; Luu Rebeccah J. | Zendy; Nam Jin | Zendy

Premium

Enhanced Lineage‐Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds

Author(s) -

Maldonado Maricela,

Ico Gerardo,

Low Karen,

Luu Rebeccah J.,

Nam Jin

Publication year - 2016

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201600141

Subject(s) - induced pluripotent stem cell , stem cell , human induced pluripotent stem cells , tissue engineering , microbiology and biotechnology , regenerative medicine , cellular differentiation , directed differentiation , materials science , embryonic stem cell , biology , genetics , gene

Electrospun scaffolds with varied stiffness promote distinct colony morphology of human induced pluripotent stem cells, which affects their subsequent differentiation . On soft scaffolds, induced pluripotent stem cells develop 3D colonies due to the pliability of the electrospun fibrous networks, leading to greater differentiation tendency to ectodermal lineage.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research