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Enhanced Lineage‐Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds
Author(s) -
Maldonado Maricela,
Ico Gerardo,
Low Karen,
Luu Rebeccah J.,
Nam Jin
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600141
Subject(s) - induced pluripotent stem cell , stem cell , human induced pluripotent stem cells , tissue engineering , microbiology and biotechnology , regenerative medicine , cellular differentiation , directed differentiation , materials science , embryonic stem cell , biology , genetics , gene
Electrospun scaffolds with varied stiffness promote distinct colony morphology of human induced pluripotent stem cells, which affects their subsequent differentiation . On soft scaffolds, induced pluripotent stem cells develop 3D colonies due to the pliability of the electrospun fibrous networks, leading to greater differentiation tendency to ectodermal lineage.