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Phospholipid End‐Capped Acid‐Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics
Author(s) -
John Johnson V.,
Thomas Reju George,
Lee Hye Ri,
Chen Hongyu,
Jeong Yong Yeon,
Kim Il
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600126
Subject(s) - phospholipid , intracellular , micelle , polyurethane , biophysics , materials science , chemistry , biochemistry , pharmacology , medicine , membrane , biology , organic chemistry , aqueous solution
Nanoscale drug carriers fabricated by phospholipid end‐capped polyurethane bearing acetal backbones that degrade in acidic conditions are fabricated. These micelles effectively allow drugs to enter the blood circulation, and then disintegrate in acidic endosomes and lysosomes for intelligent delivery of payloads.