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Oxygen Nanocarrier for Combined Cancer Therapy: Oxygen‐Boosted ATP‐Responsive Chemotherapy with Amplified ROS Lethality
Author(s) -
Zhao Pengfei,
Zheng Mingbin,
Luo Zhenyu,
Fan Xiujun,
Sheng Zonghai,
Gong Ping,
Chen Ze,
Zhang Baozhen,
Ni Dapeng,
Ma Yifan,
Cai Lintao
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600121
Subject(s) - nanocarriers , endocytosis , intracellular , cancer cell , magic bullet , chemistry , reactive oxygen species , cancer , cancer research , drug delivery , biophysics , biochemistry , cell , medicine , biology , bioinformatics , genetics , organic chemistry
Oxygen nanocarrier (A/D‐ONC) with a polymeric core entrapping hemoglobin and a cationic lipid shell absorbing a DOX‐intercalating DNA duplex is developed. After endocytosis oxygenated A/D‐ONC donates O 2 to cancer cells that acts therapeutically by: (1) increasing intracellular ATP content that promotes DOX release, thereby converting ATP to the trigger of detrimental chemotherapy; (2) by synchronously increasing the ROS amount to amplify the lethality to cancer cells.