Oxygen Nanocarrier for Combined Cancer Therapy: Oxygen‐Boosted ATP‐Responsive Chemotherapy with Amplified ROS Lethality | Zendy

Zhao Pengfei | Zendy; Zheng Mingbin | Zendy; Luo Zhenyu | Zendy; Fan Xiujun | Zendy; Sheng Zonghai | Zendy; Gong Ping | Zendy; Chen Ze | Zendy; Zhang Baozhen | Zendy; Ni Dapeng | Zendy; Ma Yifan | Zendy; Cai Lintao | Zendy

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Oxygen Nanocarrier for Combined Cancer Therapy: Oxygen‐Boosted ATP‐Responsive Chemotherapy with Amplified ROS Lethality

Author(s) -

Zhao Pengfei,

Zheng Mingbin,

Luo Zhenyu,

Fan Xiujun,

Sheng Zonghai,

Gong Ping,

Chen Ze,

Zhang Baozhen,

Ni Dapeng,

Ma Yifan,

Cai Lintao

Publication year - 2016

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201600121

Subject(s) - nanocarriers , endocytosis , intracellular , cancer cell , magic bullet , chemistry , reactive oxygen species , cancer , cancer research , drug delivery , biophysics , biochemistry , cell , medicine , biology , bioinformatics , genetics , organic chemistry

Oxygen nanocarrier (A/D‐ONC) with a polymeric core entrapping hemoglobin and a cationic lipid shell absorbing a DOX‐intercalating DNA duplex is developed. After endocytosis oxygenated A/D‐ONC donates O 2 to cancer cells that acts therapeutically by: (1) increasing intracellular ATP content that promotes DOX release, thereby converting ATP to the trigger of detrimental chemotherapy; (2) by synchronously increasing the ROS amount to amplify the lethality to cancer cells.

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