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Osteoanabolic Implant Materials for Orthopedic Treatment
Author(s) -
Ding YunFei,
Li Rachel W.,
Nakai Masaaki,
Majumdar Trina,
Zhang DongHai,
Niinomi Mitsuo,
Birbilis Nick,
Smith Paul N.,
Chen XiaoBo
Publication year - 2016
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201600074
Subject(s) - biocompatibility , materials science , coating , osteoblast , osteoporosis , implant , biomedical engineering , bone healing , orthopedic surgery , dentistry , composite material , medicine , metallurgy , surgery , chemistry , in vitro , biochemistry
Osteoporosis is becoming more prevalent due to the aging demographics of many populations. Osteoporotic bone is more prone to fracture than normal bone, and current orthopedic implant materials are not ideal for the osteoporotic cases. A newly developed strontium phosphate (SrPO 4 ) coating is reported herein, and applied to Ti‐29Nb‐13Ta‐4.6Zr (wt%), TNTZ, an implant material with a comparative Young's modulus to that of natural bone. The SrPO 4 coating is anticipated to modulate the activity of osteoblast (OB) and osteoclast (OC) cells, in order to promote bone formation. TNTZ, a material with excellent biocompatibility and high bioinertness is pretreated in a concentrated alkaline solution under hydrothermal conditions, followed by a hydrothermal coating growth process to achieve complete SrPO 4 surface coverage with high bonding strength. Owing to the release of Sr ions from the SrPO 4 coating and its unique surface topography, OB cells demonstrate increased proliferation and differentiation, while the cellular responses of OC are suppressed, compared to the control case, i.e., bare TNTZ. This TNTZ implant with a near physiologic Young's modulus and a functional SrPO 4 coating provides a new direction in the design and manufacture of implantable devices used in the management of orthopedic conditions in osteoporotic individuals.