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Nanomedicine: In Vivo Gene‐Silencing in Fibrotic Liver by siRNA‐Loaded Cationic Nanohydrogel Particles (Adv. Healthcare Mater. 18/2015)
Author(s) -
Kaps Leonard,
Nuhn Lutz,
Aslam Misbah,
Brose Alexander,
Foerster Friedrich,
Rosigkeit Sebastian,
Renz Patricia,
Heck Rosario,
Kim Yong Ook,
Lieberwirth Ingo,
Schuppan Detlef,
Zentel Rudolf
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570101
Subject(s) - nanomedicine , in vivo , gene silencing , fibrosis , microbiology and biotechnology , cancer research , cationic polymerization , chemistry , materials science , medicine , gene , nanotechnology , pathology , biology , biochemistry , nanoparticle , organic chemistry
Knocking down collagen synthesis in liver fibrosis: On page 2809, D. Schuppan, R. Zentel, and co‐workers show how systemically administered cationic nanohydrogel particles loaded with anti‐Col1α1 siRNA target fibrogenic effector cells in the liver and thereby suppress collagen synthesis and attenuate fibrosis (Cover design: Cristina Sala).