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Bioimaging: Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages? (Adv. Healthcare Mater. 17/2015)
Author(s) -
Faucon Adrien,
BenhelliMokrani Houda,
Córdova Luis A.,
Brulin Bénédicte,
Heymann Dominique,
Hulin Philippe,
Nedellec Steven,
Ishow Eléna
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570097
Subject(s) - solvatochromism , fluorescence , nanoparticle , vesicle , nanotechnology , materials science , biophysics , chemistry , biology , membrane , biochemistry , optics , physics
Fluorescent organic nanoparticles (FONs), made of self‐assembled solvatochromic fluorophores, represent a novel class of bright imaging agents. On page 2727, E. Ishow and co‐workers show how in cellulo studies evidence dramatic dissembling of FONs by macrophages compared to cancer cells. Macrophages disintegrate internalized yellow‐emitting FONs and expulse the individual components by excreting vesicles. Strong green fluorescence arises from the solvatochromic fluorophores dissolved in the rich lipid content of vesicles (Cover design: Nicolas Gazut).