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Role of Shape in Tumor Environment: Cubical Shape Enhances the Interaction of Layer‐by‐Layer Polymeric Particles with Breast Cancer Cells (Adv. Healthcare Mater. 17/2015)
Author(s) -
Alexander Jenolyn F.,
Kozlovskaya Veronika,
Chen Jun,
Kuncewicz Thomas,
Kharlampieva Eugenia,
Godin Biana
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570096
Subject(s) - materials science , biocompatible material , layer (electronics) , nanotechnology , scanning electron microscope , confocal , breast cancer , elasticity (physics) , confocal microscopy , biomedical engineering , biophysics , cancer , composite material , optics , medicine , biology , physics
Understanding the role of shape and elasticity in the behavior of objects in the tumor microenvironment is crucial for designing more efficient and less toxic therapies. On page 2657, E. Kharlampieva, B. Godin, and co‐workers explore spherical and cubic biocompatible elastic microshells and their rigid core–shell precursors. The cover image, which is a superimposition of confocal (cells and particles) and scanning electron (particles) micrographs, illustrates how the cubic shape promotes the interaction of particles with breast cancer cells.