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Bone Tissue Engineering: Electrospun Polycaprolactone 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering (Adv. Healthcare Mater. 15/2015)
Author(s) -
Xu Tao,
Miszuk Jacob M.,
Zhao Yong,
Sun Hongli,
Fong Hao
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570089
Subject(s) - scaffold , endochondral ossification , tissue engineering , extracellular matrix , polycaprolactone , mesenchymal stem cell , materials science , biomedical engineering , bone tissue , microbiology and biotechnology , anatomy , cartilage , medicine , biology , composite material , polymer
On page 2238, H. Sun, H. Fong, and co‐workers report that electrospun PCL 3D nanofibrous scaffold with interconnected and hierarchically structured pores is morphologically/structurally similar to natural extracellular matrix (ECM), hence well‐suited for cell functions and tissue formation. The in vitro results indicate that the novel scaffold supports mouse bone marrow mesenchymal stem cells' osteogenic differentiation, while the in vivo results suggest that it acts as favorable synthetic ECM for the physiological process of endochondral ossification.