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Drug Release: Temporally Tunable, Enzymatically Responsive Delivery of Proangiogenic Peptides from Poly(ethylene glycol) Hydrogels (Adv. Healthcare Mater. 13/2015)
Author(s) -
Van Hove Amy H.,
Antonienko Erin,
Burke Kathleen,
Brown Edward,
Benoit Danielle S. W.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570078
Subject(s) - self healing hydrogels , ethylene glycol , drug delivery , linker , biophysics , fluorescence microscope , materials science , drug , chemistry , fluorescence , nanotechnology , polymer chemistry , pharmacology , organic chemistry , medicine , biology , optics , physics , computer science , operating system
On p. 2002, D.S.W. Benoit and co‐workers describe the first approach to temporally control enzymatically responsive drug release. The background shows the vascularization induced by the enzymatically responsive hydrogels, imaged using multiphoton fluorescence microscopy. Overlaid on this background are schematic depictions of hydrogels releasing drug slowly or quickly, depending on the enzymatically degradable linker use. A cell expressing enzymes is depicted showing the enzymatically mediated release.