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Nonlinear Optics: NIR‐Triggered Drug Delivery by Collagen‐Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015)
Author(s) -
Barhoumi Aoune,
SalvadorCulla Borja,
Kohane Daniel S.
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570046
Subject(s) - second harmonic generation , materials science , drug delivery , nonlinear optics , fluorescence , molecule , nonlinear optical , optoelectronics , fluorescein , nanotechnology , optics , nonlinear system , chemistry , laser , organic chemistry , physics , quantum mechanics
In the study presented by D. S. Kohane and co‐workers on page 1159, fluorescein molecules are initially bound to collagen fibers through UV‐sensitive bonds. Collagen fibers are exposed to NIR light, which is upconverted to UV light through second harmonic generation. The UV‐sensitive bonds absorb the upconverted UV light and undergo an irreversible cleavage releasing the fluorescein molecules.