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Drug Delivery: pH‐Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent (Adv. Healthcare Mater. 6/2015)
Author(s) -
Sun Diankui,
Ding Jianxun,
Xiao Chunsheng,
Chen Jinjin,
Zhuang Xiuli,
Chen Xuesi
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201570035
Subject(s) - pegylation , prodrug , internalization , in vivo , pharmacology , cytotoxicity , drug delivery , chemistry , drug , in vitro , nanotechnology , materials science , biochemistry , medicine , cell , polyethylene glycol , organic chemistry , biology , microbiology and biotechnology
A reversible PEGylated prodrug integrates the advantages of PEGylation and responsiveness. J. Ding and colleagues reveal on page 844 that the prodrug exhibits acid‐accelerated drug release, improved cellular internalization and cytotoxicity in vitro, and upregulated intratumoral accumulation, antitumor efficacy, and security in vivo.